100 %     1 out of 1 reviewer(s) would follow this procedure again.
Undergraduate Student
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Level 1 Reviewer
Member since : 03/2016

1 Reviews
1 Helpful votes

Posted on :
04/16/2016 14:54

Yield of (isolated) product

ee (if applicable)

Reaction Set-up

Workup and Isolation

Availability of reagents

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Air-stable product
Moisture-stable product
Commercial reactants/reagents

The reaction procedure for this Appel reaction of nerol is easy to follow and I ran on a 10-gram scale. The PPh3 was added in portions but still dissolved really slow. I used hexanes instead of pentane to extract the product from PPh3 and its oxides. I did not run a column and proceeded with the crude from work-up.

Percent yield: 77%